The relation between VLDL-cholesterol and risk of cardiovascular events in patients with manifest cardiovascular disease

Abstract Introduction Apolipoprotein B containing lipoproteins are atherogenic. There is evidence that with low plasma density lipoprotein cholesterol (LDL-C) levels residual vascular risk might be caused by triglyceride rich such as very-low (VLDL), chylomicrons and their remnants. We investigated the relationship between VLDL-cholesterol (VLDL-C) recurrent major adverse cardiovascular events (MACE), limb (MALE) all-cause mortality in a cohort of patients disease. Methods Prospective study 8057 disease from UCC-SMART study. The relation calculated VLDL-C occurrence MACE, MALE was analyzed Cox regression models. Results Patients mean age 60 ± 10 years, 74% were male, 4894 (61%) had coronary artery disease, 2445 (30%) stroke, 1425 (18%) peripheral arterial 684 (8%) an abdominal aorta aneurysm at baseline. A total 1535 571 1792 deaths observed during median follow up 8.2 years (interquartile range 4.512.2). not associated MACE or mortality. In highest quartile higher for (HR 1.49; 95%CI 1.16–1.93) compared to lowest quartile, after adjustment confounders including LDL-C lipid lowering medication. Conclusion clinically manifest confers increased MALE, but mortality, independent established factors lipid-lowering